HCAR1-mediated lactate signaling modulates motor behavior and regulates spontaneous firing in Purkinje cells
iScience 2026, 29:116930
DOI: https://doi.org/10.1016/j.isci.2026.116930
DOI: https://doi.org/10.1016/j.isci.2026.116930
Highlights
- HCAR1-mediated lactate signaling is required for motor stability and motor learning
- HCAR1 is a novel modulator of spontaneous Purkinje cell firing
- HCAR1-mediated lactate signaling modulates HCN channels in Purkinje cells
