Astrocyte Mitochondrial UCP4 Reprograms Neuronal Network Oscillations via GDNF-Dependent K+-Ca2+ Signaling in Alzheimer’s Disease Mice
Aisylu Gaifullina, Chaima Belhi, Leonardo Restivo, & Jean-Yves Chatton
Cells 2026, 15(7), 597
What are the main findings?
-
-
Astrocytic UCP4 overexpression normalizes neuronal excitability and hippocampal/subicular microcircuits via modulation of ionic membrane currents in 3xTG Alzheimer’s disease mouse model.
-
Astrocyte UCP4 upregulation increases GDNF levels, a neurotrophic factor known to support neuronal function.
-
What is the implication of the main finding?
-
-
Astrocyte UCP4 promoting GDNF signaling represents a promising strategy for enhancing neuronal resilience in neurodegeneration.
-
Targeting astrocyte mitochondria shows therapeutic potential even in symptomatic Alzheimer’s disease mice.
-
