After axonal injury, severed axons degenerate within a day in many species, including humans, monkeys, and mice. However, in other species, they fail to degenerate, and their synapses remain functionally preserved. Here, Maria identified the local translatome required to functionally sustain these synapses, using a model of impaired Wallerian degeneration in Drosophila.
The Terenzio lab at OIST (Japan) and Leonardo Restivo from the Neuro-BAU Unit at UNIL generously supported this project.
The article is accessible on EMBO reports.
