The research proposal, entitled « Regulation of prodegenerative nicotinamide mononucleotide in Drosophila neurons », focuses on the vitamin B3 derivative NMN, which is at the intersection of healthy aging and neurodegeneration. Research in the lab aims to determine how levels of NMN are established in neurons and their axons. It may clarify how bolstered NAD+ homeostasis by vitamin B3 supplementation is beneficial for some, unnecessary for others, and potentially harmful for a few humans.
